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Mikhail Nikiforov is a Professor in the Department of Pathology at Duke University, with a significant research focus on the mechanisms of deregulated GTP metabolism in cancer cells. His work investigates how GTP-binding proteins contribute to cellular processes and their dysregulation in human cancers. Through the use of genetically encoded biosensors, he has explored free GTP fluctuations and their correlation with the activity of small RHO-GTPases, such as RAC1 and RHOA. His research is particularly focused on multiple myeloma, elucidating the complex metabolic and transcriptional changes that contribute to drug resistance, especially in response to proteasome inhibition. Nikiforov employs a combination of metabolomics and transcriptomics in his studies, identifying key enzymes and transcription factors that inform our understanding of cellular survival and phenotypic transitions during malignancy. His interests also include the regulation of epithelial-mesenchymal transition in melanoma, mediated by factors like FOXQ1. In addition to his research, he offers courses related to innovative studies in biomedical engineering and pathology, reflecting his dedication to educating the next generation of scientists.
Duke University • Durham, NC
Leading research and education in cancer biology and biomedical engineering.
Department of Biomedical Engineering (MS program)