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Professor Ming Guo's laboratory focuses on interface mechanics, physics, and cell biology, seeking to understand how the physical properties of biological functions affect cellular systems. His research emphasizes the mechanical processes that underlie a range of higher-level phenomena related to health and disease, including cancer, cardiovascular disease, malaria, and morphogenesis. Professor Guo has developed and applied novel techniques to measure the mechanical properties of cellular forces at single-cell and multiple-cell levels in both 2D and 3D contexts. Methods like Force Spectrum Microscopy and high-frequency microrheology are utilized to explore the activity-driven random transport mechanisms of cells and the influence of cytoplasmic mechanics on transport processes. His current research aims to control the behavior and functionality of cells and tissues using engineering approaches. Professor Guo leads an interdisciplinary team of engineers, biologists, and physicists to investigate valuable insights into the physical property impacts of living cells on human health and disease, applying mechanical cues to guide developmental processes and prevent disease.