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Ming Zhang’s main research program focuses on the roles of tumor suppressors in normal development and the progression of breast and prostate cancer, particularly through the study of Maspin and Ets transcription factor PDEF. Maspin, a unique member of the SERPIN family, plays significant roles in normal tissue development, tumor metastasis, and angiogenesis. His laboratory has conducted genetic studies utilizing maspin transgenic knockout mice, demonstrating its critical involvement in normal mammary and prostate development. Furthermore, Zhang's lab seeks to identify immune components that regulate breast cancer metastasis and explores the effects of chronic inflammation on tumor progression. Through innovative animal models, they study tumor-immune cell interactions and investigate genes involved in chronic inflammation and tumor evolution.
Northwestern University Feinberg School of Medicine • Chicago, IL
Research and teaching in the Department of Biochemistry and Molecular Genetics.
Administered by The Graduate School; focuses on Biomechanics, Imaging, Biomaterials, and Regenerative Medicine.