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Dr. Minglei Zhao is an Associate Professor in the Biological Sciences Division at the University of Chicago. His research focuses on critical molecular mechanisms and structural biology pertaining to complex molecular machines involved in human disease. He has a prominent interest in AAA+ ATPases, specifically p97, and their roles in protein homeostasis and neurodegenerative diseases. His lab utilizes advanced techniques, including cryo-electron microscopy and X-ray crystallography, to investigate the intricacies of protein structures and their interactions with ubiquitin chains. The findings from his research aim to illuminate the molecular mechanisms underlying p97 and large vault ribonucleoprotein particles, which are pivotal in understanding drug resistance in cancer cells. Dr. Zhao's academic background includes a Ph.D. in Molecular Biology from the University of California, Los Angeles, and a Bachelor's degree in Biological Sciences from Fudan University in Shanghai, China. His contributions also extend to various publications in reputable journals, highlighting his expertise in structural biology and biochemistry. He is committed to understanding the structural basis of complex regulatory mechanisms in cellular processes, making significant impacts in the field of molecular biology and medicine.
University of Chicago • Chicago, IL, USA
Conducting research and teaching in the Biological Sciences Division, focusing on molecular mechanisms involving protein complexes.
Department of Philosophy