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Minglei Zhao is an Associate Professor at the University of Chicago specializing in structural biology. His research focuses on understanding the mechanisms of molecular machines and their roles in human diseases. Currently, his work primarily targets the p97/ubiquitination system, a vital hub for cellular protein homeostasis associated with neurodegenerative diseases and cancer drug resistance. His lab investigates molecular architectures involving the p97 complex and its cofactor proteins, aiming to elucidate the molecular mechanisms tied to p97 and its ubiquitin chains topology. Additionally, Zhao explores the vault complex, the largest ribonuclear protein in eukaryotes, to unravel its elusive function, particularly related to drug resistance in cancer cells. His lab employs techniques such as X-ray crystallography and cryo-electron microscopy to further his research goals.
Department of Philosophy