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Minglei Zhao is an Associate Professor in the Department of Biochemistry and Molecular Biophysics at the University of Chicago. His research focuses on understanding the mechanisms of molecular machines and their roles in human diseases, particularly through the study of the p97/ubiquitination system and vault ribonucleoproteins (RNP). He utilizes advanced techniques such as X-ray crystallography and cryo-electron microscopy to investigate the structural dynamics and molecular architecture of these complexes. His findings aim to elucidate the molecular mechanisms governing protein homeostasis and the implications of these mechanisms in neurodegenerative diseases and cancer treatment. Additionally, he has explored the role of copper-sensing mechanisms in cellular signaling pathways, contributing to the broader understanding of how metal levels influence protein function and gene expression.
Department of Philosophy