Professor Dr. Miriam Stoeber

Biography

Prof. Miriam Stoeber leads a laboratory focused on subcellular control receptor signaling, particularly within the realm of G protein-coupled receptors (GPCRs), which are known as nature’s largest receptor family. Her research explores the activation of GPCRs by a diverse array of ligands, including neurotransmitters and hormones, and their roles in physiology and disease. Understanding that ligand-selective signaling can drive ongoing drug development, her laboratory investigates the distinct pathways initiated by various ligands in cellular contexts. A significant emphasis is placed on opioid receptors, whose interactions with opioid drugs, such as morphine and fentanyl, present both therapeutic benefits and risks due to their potential for addiction. By utilizing advanced techniques such as live-cell microscopy and novel biosensors, her group dissects the clinically relevant GPCR signaling systems to unveil the complexities of drug action and pathology.

Research Interests