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Mohammad-Reza Ghovanloo is an Associate Research Scientist and Associate Director for Drug Discovery at the Center for Neuroscience and Regeneration Research at Yale School of Medicine. His research integrates ion channel biophysics, neurophysiology, and pharmacology to uncover the chemical and physical interactions that regulate neuronal excitability. By employing high-throughput electrophysiology and modeling, his work aims to identify and optimize next-generation therapeutics for pain and neurological disorders. Ghovanloo's research has established mechanistic frameworks explaining how cannabinoids, such as cannabidiol (CBD) and cannabigerol (CBG), modulate voltage-gated sodium channels. His studies have revealed that these cannabinoids can stabilize inactive channel states and alter membrane elasticity to fine-tune neuronal excitability. He has received multiple fellowships and has been recognized with various awards and invitations for talks, contributing to media features in prominent outlets. Ghovanloo reviews for several academic journals and aims to advance the field of translational neurophysiology by integrating mechanistic discovery with scalable approaches in ion channel pharmacology.
Yale University • New Haven, CT
Conducting research on ion channel behavior, focusing on pain and neurological disorders.
Xenon Pharmaceuticals • Canada
Contributed to the discovery and characterization of small-molecule modulators for voltage-gated ion channels.
Administered via the Graduate School of Arts and Sciences (GSAS). GRE General is optional for PhD.