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Montserrat C Anguera, PhD, is a faculty member in the Biomedical Graduate Studies at the Perelman School of Medicine, University of Pennsylvania. Her research focuses on X-chromosome Inactivation and its implications in the immune system and stem cells. She investigates the epigenetic mechanisms involving long noncoding RNAs, specifically in early human development and placental progenitor cells. Anguera aims to understand the molecular mechanisms behind X-Chromosome Inactivation and how the alteration of dosage in X-linked genes may impact embryonic development, as well as contribute to sex-biased diseases, particularly autoimmune disorders like lupus, which exhibit strong female bias and involve overexpression of X-linked immune-related genes. Her lab's significant findings include the discovery of inactive X euchromatic features in female lymphocytes and how these mechanisms affect lymphocyte activation, thereby advancing the knowledge of female-biased autoimmune disorders. Additionally, Anguera studies the role of long noncoding RNAs in regulating innate immune responses in human placental progenitors, contributing to the understanding of sex-specific placental development.
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