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Professor Murray Esler's principal research contribution is the development of isotope dilution methodology to study the human sympathetic nervous system. His application of this tool investigates sympathetic neural physiology in relation to circulatory control, aging, exercise, and mental stress responses. Professor Esler's work extends to neural cardiovascular pathophysiology, obesity, orthostatic intolerance, panic disorders, depressive illness, cardiac failure, and essential hypertension, making significant contributions to the field of human cardiovascular neuroscience. His research has demonstrated high levels of activation of cardiac sympathetic outflow in patients with heart failure, providing a theoretical backdrop for the evaluation of beta-adrenergic blockers in the condition. He has also shown the activation of renal sympathetic outflow in essential hypertension and has helped in the development of new therapies, including radio-frequency ablation of renal sympathetic nerves using purpose-designed renal artery catheters.
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