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Nader Sheibani is a Professor in the Department of Ophthalmology and Visual Sciences at the University of Wisconsin-Madison. His research focuses on the role of oxidative stress in the pathogenesis of diabetic retinopathy. He has conducted numerous studies to detail the molecular and cellular mechanisms involved, aiming to understand the key biochemical steps that lead to oxidative stress injury in the diabetic eye. His hypothesis involves mitochondrial carbonic anhydrases as critical regulators of oxidative stress in retinal perivascular supporting cells, and he explores their activity's role in preserving the integrity and function of retinal vasculature in the context of diabetes. His innovative approach includes using pharmacological methods such as topiramate to inhibit mitochondrial carbonic anhydrases and employing genetic engineering techniques to silence these genes in murine models of diabetic retinopathy, aiming to recapitulate features of human disease. His work not only seeks to unravel the causes of metabolic stress in retinal cells but also aspires to determine protective strategies against microvascular complications associated with diabetes, neuropathy, nephropathy, and Alzheimer's disease.
Department: Department of Computer Sciences