Dr. Nancy Spinner

Biography

Nancy B. Spinner is a professor in the Department of Genetics at the Perelman School of Medicine at the University of Pennsylvania. She specializes in human genetics, with a focus on Notch signaling in human diseases, particularly Alagille syndrome and biliary atresia. Her research aims to identify genetic factors that contribute to congenital diseases and their clinical variations. Spinner has been pivotal in demonstrating that the disorders associated with the Notch signaling pathway are caused by genetic mutations. Her laboratory is currently investigating genetic susceptibility to biliary atresia and employs a range of techniques including genome-wide association studies and whole exome sequencing. She collaborates with Dr. Ian Krantz on projects that explore the ethical and psychosocial implications of genetic research. Spinner is also engaged in characterizing the mechanisms behind ring chromosome syndromes, with a specific interest in understanding the molecular basis for clinical features observed in affected patients.

Research Interests

Experience