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Napoleone Ferrara, M.D., is a Distinguished Professor in Pathology at the University of California, San Diego. He holds adjunct professorships in Ophthalmology and Pharmacology, and he is the Hildyard Endowed Chair for Eye Disease. Ferrara's primary research interests focus on the biology of angiogenesis, particularly the identification of its regulators. In 1989, he was instrumental in isolating and cloning vascular endothelial growth factor (VEGF), and his subsequent studies have demonstrated VEGF's critical role as a regulator of both normal and pathological angiogenesis. His research established that inhibition of VEGF can suppress tumor growth in various cancers, leading to the development of humanized anti-VEGF monoclonal antibodies like Bevacizumab, which has received FDA approval for multiple cancer indications. Furthermore, his discovery of VEGF as a key mediator of angiogenesis in intraocular neovascular syndromes paved the way for clinical therapies, including Ranibizumab for neovascular age-related macular degeneration and other ocular vascular disorders.
Administered by the Scripps Institution of Oceanography. Curricular groups include Climate-Ocean-Atmosphere (COAP), Geosciences (GEO), and Ocean Biosciences (OBP).