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Dr. Avadhani's laboratory focuses on aspects of mitochondrial genetics and the regulation of mitochondrial membrane biogenesis in mammalian cells. The research includes mechanisms of dual targeting of cytochrome P450-related proteins in both the endoplasmic reticulum and mitochondria, elucidating the activation mechanisms of chimeric N-terminal signals by cAMP and physiological factors. Additionally, it characterizes novel mitochondria-to-nucleus stress signaling pathways in cells subjected to mitochondrial-specific genetic and metabolic stress, highlighting the role of altered calcium signaling in tumor progression and metastasis. Furthermore, the research investigates the regulation of cytochrome oxidase gene expression and the modulation of enzyme assembly and activity under conditions of chemical oxidative stress. A significant focus is also placed on the role of mitochondrial stress signaling in embryonic stem cell function and differentiation, particularly under conditions of chemical oxidative stress.
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