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Neil J. Freedman is a Professor in the Department of Medicine and the Department of Cell Biology at Duke University. His research focuses on understanding the signal transduction mechanisms involved in atherosclerosis, including the genetic underpinnings of atherosclerosis and vein graft failure. His work investigates the regulation of receptor protein tyrosine kinases and G protein-coupled receptor kinases, as well as the role of β-arrestins in atherosclerosis and the molecular mechanisms of atherogenesis associated with dual Rho-GEF kalirin and the small nucleolar RNAs from the Rpl13a locus. Moreover, he employs in vivo modeling to study atherosclerosis and neointimal hyperplasia using mouse models, analyzing carotid artery bypass grafting and gene-deleted congenic wild type mice. Freedman's methodology includes a focus on receptor phosphorylation, intracellular trafficking, and comprehensive studies using primary smooth muscle cells, endothelial cells, and macrophages derived from knockout mice subjected to RNA interference treatments. His research is pivotal in advancing the understanding of the pathophysiology of atherosclerotic diseases.
Department of Biomedical Engineering (MS program)