Dr. Nelson Lamarche

Biography

Nelson LaMarche is an Assistant Professor in the Department of Pathology and the Cancer Biology Institute at Yale Cancer Center. He obtained his Ph.D. in Immunology from Harvard University, where he researched the role of the immune system in controlling adipose tissue physiology and metabolic homeostasis. Following this, he pursued postdoctoral studies at the Icahn School of Medicine at Mount Sinai, focusing on cancer immunotherapy and myeloid cells. His notable discovery of the cytokine interleukin-4 (IL-4) produced by bone marrow lung cancer led to the development of a clinical trial involving IL-4R blocking antibody dupilumab, which has been marketed as Dupixent for advanced lung cancer. His current research aims to develop myeloid-targeted immunotherapies for cancer, particularly examining how tumors communicate with distant organs to alter normal physiology and subvert antitumor immune responses. LaMarche's lab integrates themes of metabolism, tissue immunology, and hematopoiesis, emphasizing that cancer is a systemic disease that affects normal organ function and controls immune responses.

Research Interests