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Nicholas Matheson is a clinician scientist involved in the study of viral cellular regulation and immunometabolism at the University of Cambridge. His research primarily focuses on the study of host-virus interactions, providing critical insights into viral pathogenesis and the essential aspects of cell biology. He has pioneered the use of Stable Isotope Labelling Amino Acids in Cell Culture (SILAC) and Tandem Mass Tag (TMT)-based functional proteomics to compare the expression of intracellular and cell surface proteins during viral infections. With over 40 million people infected with Human Immunodeficiency Virus (HIV) worldwide, which causes over a million AIDS-related deaths annually, understanding the virus and its interactions with host cells is vital. Matheson’s research identifies novel proteins and processes targeted by various viruses, including HIV, and explores the manipulation of metabolism to influence immune responses. Additionally, during the COVID-19 pandemic, he contributed significantly to the development of luminescent reporter cells for testing antiviral drugs and measuring neutralizing antibodies, which facilitated his involvement in several COVID-19 vaccine research projects funded by UK Research Innovation. His work has greatly influenced our understanding of viral immunobiology and therapeutic approaches.
University of Cambridge • Cambridge, ENG
Leading research on viral cellular regulation and immunometabolism, focusing on HIV and its interactions with host immune response.
Standard postgraduate requirements for Department of Politics and International Studies (POLIS) and related humanities departments.