Dr. Nick Brown

Biography

Professor Nick Brown's research focuses on molecular analysis of morphogenesis, cellular adhesion, and communication vital for development in multicellular organisms. His work extensively utilizes proteins that allow cells to adhere and convey signals, influencing cellular responses to their environment. Currently, his research targets adhesion receptors linked to the cytoskeleton and how these determine cell shape and movement during the development of animals. His investigations into the cytoskeleton reveal its contractile abilities, which adaptively alter force at adhesion sites, especially under varying biochemical signals. Notably, using the fruit fly Drosophila as a model, he explores the complex mechanisms connecting cell adhesion to the cytoskeleton and their contribution to morphogenesis. Brown is particularly interested in identifying adhesion receptors that forge dynamic yet crucial stable connections within physiological structures. His methodology includes combining quantitative imaging techniques with genetics to elucidate the principles governing the assembly of integrin adhesion complexes and their mechanosensitive properties. His groundbreaking work has revealed a novel adhesion subcomplex influenced by dynamic microtubules that are essential for maintaining segmental boundaries during embryonic epidermis formation.

Research Interests