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Nick Lakin is a Professor of Biochemistry with a focus on DNA damage detection, signaling, and repair. His research explores the critical importance of preserving the integrity of genetic material for health, as defects can lead to mutations and a variety of diseases, including cancer. Lakin's long-standing interest lies in understanding the systems that detect DNA damage and signal cellular responses to initiate repair. A central theme in his work is the study of Poly ADP-ribose polymerases (PARPs), which play a key role in the cellular response to DNA damage by detecting breaks in the DNA double helix and facilitating the recruitment of repair proteins. Recently, his research has identified different types of PARPs that respond to various forms of DNA damage, focusing on their regulation and the recruitment mechanisms involved. His overarching goal is to comprehend the defects in DNA repair that lead to cancer, with the aim of leveraging this knowledge to develop targeted cancer therapies.
Department of Politics and International Relations - Higher Level English requirement.