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Dr. Dulin’s laboratory investigates signaling mechanisms related to transforming growth factor beta-induced myofibroblast differentiation and its pathogenesis in pulmonary fibrosis, utilizing cell culture and animal models. His studies elucidated the critical role of serum response factor in myofibroblast differentiation and the control of actin and microtubule dynamics. Dr. Dulin’s research explores basic studies on the biological functions of regulators of G protein signaling (RGS) proteins, focusing on RGS3, a member of this family. His group has demonstrated that RGS3 regulates signaling mediated by G protein subtypes, influencing TGF-beta signaling pathways non-canonically. Collaborating with Dr. Anne Sperling, he has established the role of RGS3 in controlling T cell migration and inflammation, employing knock-down and knockout methodologies. Current studies are investigating the function of endogenous RGS3 in relation to cancer cell growth and migration, emphasizing epithelial-mesenchymal transition dynamics. Dr. Dulin is a Principal Investigator on several NIH grants focusing on fibroblast biology in pulmonary fibrosis, investigating the control of myofibroblast activation and novel functions of RGS3.
University of Chicago • Chicago, IL
Teaching and conducting research in the Department of Medicine, focusing on pulmonary critical care.
Department of Philosophy