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Dr. Nickolai Dulin is an Associate Professor in the Biological Sciences Division at the University of Chicago. His research focuses on the signaling mechanisms involved in TGF-beta-induced myofibroblast differentiation and its relation to the pathogenesis of pulmonary fibrosis. His laboratory employs both cell culture and animal models to investigate the critical roles of serum response factor (SRF) in myofibroblast differentiation and its impact on actin and microtubule dynamics. Furthermore, his research explores the basic functions of regulators of G protein signaling (RGS) proteins, particularly RGS3, and their influence on TGF-beta signaling pathways. Collaboratively with Dr. Anne Sperling, he has established the role of RGS3 in T cell migration related to T cell-mediated inflammation. Current investigations in his lab are directed towards understanding the function of endogenous RGS3 in cancer cell growth and migration, as well as epithelial-mesenchymal transition (EMT). Dr. Dulin's notable contributions include his works on LRRC8A-containing anion channels and their role in glioblastoma proliferation.
University of Chicago • Chicago, IL
Conducts research and teaches in the field of cancer biology and pulmonary fibrosis.
Department of Philosophy