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Nicole Calakos is a distinguished professor in the Department of Neurology at Duke University. Her research focuses on synaptic plasticity, the process by which neuronal connections change in response to experience. This is crucial for understanding how memories are formed, habits established, and how these processes can go awry in neurological diseases. Her work delves into the molecular mechanisms of synaptic plasticity, particularly in the context of basal ganglia circuitry, which is integral to movement and learning. Calakos lab utilizes advanced methodologies, including electrophysiology and two-photon calcium imaging, to explore the function of striatal medium spiny neurons in both normal and pathological states. The lab aims to identify therapeutic interventions for disorders such as Parkinson’s disease, OCD, and dystonia, leveraging insights gained from various models to develop innovative strategies for treatment.
Department of Biomedical Engineering (MS program)