Dr. Nicole Green

Biography

Dr. Nicole Green is a Research Associate at the School of Biotechnology and Biomolecular Science. Her PhD research focused on enhancers and non-coding genetic regulatory regions, particularly in primary human astrocytes, contributing to our understanding of glial cell subtype behaviors in the brain. Dr. Green's work demonstrated how enhancers harbor mutations that can lead to complex diseases, including neurodevelopmental and neurodegenerative disorders, acting in a cell-type specific manner. Throughout her PhD, she performed large-scale characterization of candidate enhancers and their gene targets using CRISPR interference and single-cell RNA sequencing. A major highlight of her research includes the functional characterization of astrocyte enhancers and their potential associations with Alzheimer's disease. Currently, she continues her work as a postdoctoral researcher under Prof. Irina Voineagu, focusing on investigating the role of Alzheimer's disease-associated enhancers and their function in astrocytes. Furthermore, Dr. Green is involved in studying genes associated with intellectual disability by utilizing human brain organoids, which serve as models for brain development and genetic perturbations, thus advancing our understanding of these conditions.

Research Interests