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Nien-Pei Tsai is a professor in the Molecular Integrative Physiology at the University of Illinois, focusing on the regulation of neuronal excitability and the underlying mechanisms of various neurological disorders. His research interests include neurodevelopment, signal transduction, synaptic transmission, and the pathophysiology of autism spectrum disorder and epilepsy. By utilizing molecular and cell biology, biochemistry, electrophysiology, and mouse genetics, his lab investigates the key processes that regulate excitability at multiple levels—from synaptic and neuronal to network and system levels. Tsai aims to uncover potential therapeutic targets to ameliorate these disorders and enhance our comprehension of the complexities involved. He has contributed significantly to understanding common abnormalities in synaptic excitability observed in patients with psychiatric and neurological disorders, with a specific focus on epilepsy, autism, and Alzheimer's disease.
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