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Nikolaos Sgourakis earned his Ph.D. in Biology from Rensselaer Polytechnic Institute in 2009. His research focuses on integrating simulation and experimental approaches to study intrinsically disordered proteins. He was mentored by Nobel Laureate David Baker, exploring protein complex modeling using sparse data. Sgourakis has significant experience in using biomolecular NMR spectroscopy to understand mechanisms of viral immune evasion. Currently, his independent research program addresses the targeting of Major Histocompatibility Complex (MHC) I antigen presentation pathways and applications of immunotherapy for pediatric solid tumors. He has been affiliated with the University of Pennsylvania and Children’s Hospital Philadelphia for five years, directing his focus toward the real-world impacts of his discoveries in cancer immunotherapy. The Sgourakis lab is part of the international Cancer Grand Challenges consortium, developing T-cell-based therapeutics with a combination of structural biology and computational protein engineering to enhance immune responses against various diseases, particularly cancer.
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