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The Sgourakis Lab focuses on the mechanistic molecular immunology that decodes immune function at an atomic level. It investigates dynamic molecular processes that determine immune recognition and signaling, forming long-term memory against viral, tumor, and autoimmune targets. The lab explores the molecular basis of peptide repertoire selection and the display of molecules on Major Histocompatibility Complex. Additionally, it develops CAR-based therapeutics that recognize targets on cell surfaces, which triggers T cell receptor activation at the immunological synapse. The lab seeks to address these questions through a combination of cutting-edge structural biology tools such as Nuclear Magnetic Resonance (NMR) Spectroscopy and X-ray crystallography, along with complementary biophysical and biochemical techniques, computational modeling, and functional assays. The Sgourakis Lab's efforts are fueled by close collaboration with a vibrant research community at the Children’s Hospital of Philadelphia and the University of Pennsylvania.
Sgourakis Lab • Philadelphia, PA
Leading research in molecular immunology, focusing on immune recognition, and T cell activation mechanisms.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.