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Dr. Sgourakis earned his PhD in Biology from Rensselaer Polytechnic Institute in 2009, focusing on blending simulation and experimental approaches to study intrinsically disordered proteins. He was mentored by Nobel Laureate David Baker, working on modeling structures of protein complexes using sparse data, and collaborated with Adriaan Bax at NIH to explore the use of biomolecular NMR spectroscopy to understand viral immune evasion mechanisms. His experiences laid the foundation for an independent research program focused on deciphering the targeting of MHC-I antigens and the progression of the antigen presentation pathway. With a tenure of over five years at the University of Pennsylvania and Children's Hospital Philadelphia, Dr. Sgourakis has steered his work toward immunotherapy applications for pediatric solid tumors, ensuring that discoveries have a real-world therapeutic impact. His lab is part of the international Cancer Grand Challenges consortium for 2022-2025, aiming to develop T cell-based therapeutics.
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