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Nikolay Shirokikh is a biochemist and molecular biologist whose research focuses on the mechanisms underlying the decoding of genetic information. He works on how proteins are synthesized and regulated by messenger RNA (mRNA), which is crucial for cellular functions and survival. His research particularly emphasizes the role of translational control in eukaryotic cells, investigating how cells adjust protein production in response to internal and external stimuli. He has developed high-throughput sequencing methods to explore these mechanisms in living cells and is interested in understanding and manipulating mRNA regulatory elements involved in protein synthesis regulation, especially in mammalian models. His past work includes significant projects like the creation of techniques for dissecting translation control in vivo. Nikolay's contributions extend to exploring the translation processes in response to cellular stress and cancer biology, where malignant cells exploit alternative translation pathways for survival and drug resistance.
John Curtin School of Medical Research • Canberra, Australia
Leading research initiatives on eukaryotic translation and its implications in cellular mechanisms.
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