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Norbert Perrimon's laboratory focuses on the genetic mechanisms underlying organ communication and tissue homeostasis using Drosophila models. With a commitment to exploring intercellular signaling pathways and organ regeneration, the lab employs various advanced techniques, including CRISPR, RNAi, and proximity labeling technologies, to investigate how cells respond to stressors like diet and aging. The research contributes significantly to understanding complex diseases such as diabetes and cancer by identifying novel mediators of signaling pathways, including key secreted factors. The Perrimon Lab also seeks to innovate in functional genomics, creating tools and resources that enhance the research community's capabilities, particularly through the establishment of the Drosophila RNAi Screening Center.
Harvard University • Cambridge, MA
Leading research in the areas of intercellular communication, functional genomics, and proteomics with applications in developmental biology and cancer research.
Administered by the Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (GSAS).