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Nozomi Ando is a Professor in the Department of Chemistry and Chemical Biology, at Cornell University. Her research focuses on biophysical chemical biology, particularly in understanding protein allostery and the motions of proteins involved in catalysis regulation. The Ando Lab is dedicated to developing new structural biology techniques and applying biophysical tools to study complex protein systems. One aspect of her work emphasizes the use of metalloenzymes and how these proteins, which utilize metal-containing cofactors, can perform complex chemical reactions. The lab employs small-angle X-ray scattering (SAXS) to probe the conformational landscapes of dynamic enzymes, gaining insights into protein behavior in solution. This work also includes hypothesis-driven structure determination using X-ray crystallography and cryo-electron microscopy. The lab’s innovative approaches aim to move beyond traditional crystallography, which often provides only static snapshots of proteins.
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