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Dr. Olena Jacenko's research focuses on the molecular mechanisms underlying skeletal development and blood cell differentiation. Her laboratory explores hematopoietic disorders such as bone marrow failure and immune dysfunction, as well as various cancers, establishing a connection between skeletal formation and blood cell differentiation. By generating transgenic mouse models, Dr. Jacenko has identified key relationships between cartilage structure and hematopoiesis, demonstrating how mutations in collagen X can lead to skeletal deformities and hematopoietic defects. Her multidisciplinary approach combines transgenesis with molecular biology, biochemistry, immunology, and histology to unravel the mechanisms that link skeletal and hematopoietic systems. Current projects include co-culture assays to identify defects in the marrow environment, assessments of cytokine dysregulation, and investigations into how alterations in skeletal development influence blood cell production. Dr. Jacenko's work aims to enhance understanding of the skeleto-hematopoietic link and provide insights that may inform future therapeutic strategies for related disorders.
Perelman School of Medicine, University of Pennsylvania • Philadelphia, PA
Teaching and conducting research in the area of molecular mechanisms connecting skeletal and hematopoietic processes.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.