Dr. Onn Brandman

Biography

Onn Brandman is an Associate Professor of Biochemistry at Stanford University with a courtesy appointment in Chemical Systems Biology. His research group, the Brandman Lab, focuses on understanding molecular systems-level features of protein quality control and stress responses related to health and disease. A significant aspect of his work involves Ribosome-associated Quality Control (RQC), a process that monitors defects in protein synthesis. He is notably recognized for his discovery of a protein modification termed the 'CAT tail' which targets defective proteins for degradation, a finding that has given rise to a new field within biology. His research has also pioneered methods for quantifying stress-response pathways in living systems, and he developed a new pooled screening technique called ReporterSeq, which measures the induction of transcriptional pathways under various stress conditions. Brandman's exploration of the molecular mechanisms behind protein quality control and cellular stress responses remain central to his ongoing studies, particularly in the context of viscoadaptation, which examines how cellular viscosity impacts various biological processes.

Research Interests