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Osama Al Dalahmah, MD, PhD, is an Associate Professor in the Department of Pathology and Cell Biology at Columbia University. His research laboratory is dedicated to understanding glial pathology in central nervous system (CNS) diseases, particularly the role of astrocytes in maintaining brain microenvironment homeostasis. The ultimate mission of his laboratory is to explore the heterogeneity of astrocytes across various CNS regions, define their responses to different types of injury, and discover novel astrocyte-centered therapeutic approaches for neurodegenerative diseases (NDs) and brain tumors. His primary research focuses on neurodegeneration, investigating diseases such as Huntington's disease, Parkinson's disease, Frontotemporal dementia, and Alzheimer's disease, which are characterized by neuronal loss due to astrocytic dysfunction. Additionally, Dr. Al Dalahmah emphasizes the biology of gliomas, specifically glioblastoma, a brain malignancy that challenges existing treatment strategies due to its invasive nature and ability to interact with non-neoplastic cells in the brain microenvironment. His ongoing projects utilize advanced techniques such as single cell RNA sequencing and spatial transcriptomics to identify cellular states and transcriptional programs that inform the development and testing of therapeutic targets aimed at inhibiting tumor progression.
Department of Anthropology (GSAS)