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Pamela Chang is an Associate Professor in the Department of Chemistry and Chemical Biology at Cornell University. Her research is centered on developing chemical tools to understand the immune system and probing the gut microbiome, which plays a crucial role in regulating human health and disease. Her laboratory employs biological and chemical approaches in the fields of chemical biology, molecular and cellular immunology, microbiology, organic chemistry, and biochemistry. The focus of her research includes creating activity-based probes to understand metabolic activities of the gut microbiome in relation to various disease states, characterizing small-molecule metabolites produced by gut microbiota that regulate inflammation and host defenses, and developing chemical tools to modulate immune responses using photo-immune modulators. Through these investigations, her work aims to elucidate key communication pathways between the gut microbiota and the host immune system, ultimately contributing to the understanding of immune homeostasis and its implications in the development of therapies for inflammatory diseases.
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