Dr. Paola Arlotta

Biography

The Fishell laboratory is focused on the diversity created by inhibitory interneuron subtypes. Understanding this diversity and how it is accomplished during development remains one of the most daunting problems in biology. We investigate a two-step process: first, genetic programs that create a finite number of cardinal interneuron subtypes according to their birthdate, and second, local cues that shape these subtypes for integration into distinct cortical and subcortical areas. We aim to explore the molecular controls that underlie these processes since perturbations can lead to brain dysfunctions such as autism spectrum disorder, intellectual disability, and schizophrenia. Our research also focuses on developing new tools for targeting and manipulating cortical cells, thereby enhancing our understanding of both normal and pathophysiological cortical function.

Research Interests