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Paras Anand is an Associate Professor in Innate Immunity at Imperial College London, focusing on the molecular mechanisms regulating immune responses in the context of inflammation, infection, and tissue homeostasis. His research primarily investigates intracellular signaling pathways, notably the NLRP3 inflammasome, and their regulation of cellular and lipid metabolism. His work emphasizes the role of inflammasomes, which are multiprotein complexes that respond to pathogenic microbes and endogenous danger signals, triggering the activation of caspase-1 and the release of pro-inflammatory cytokines like IL-1β and IL-18, contributing to a form of cell death known as pyroptosis. Anand’s research intersects immunology, lipid biology, and cell biology, aiming to identify therapeutic strategies to modulate inflammation in infectious diseases and chronic inflammatory disorders. He explores metabolic pathways such as fatty acid biosynthesis and cholesterol trafficking that regulate inflammasome functions and activation. His lab employs various techniques, including molecular and cellular biology, immunological imaging, and multiomics approaches to uncover insights into immune signaling and metabolic dysfunction.
Specialisms available in Materials for the Energy Transition or Theory and Simulation of Materials.