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Parashkev Nachev leads a research programme that challenges the widely held perception of the human brain as a complex organ. He focuses on creating intelligible and actionable low-dimensional models to understand brain function. His work emphasizes clinical translation as the ultimate goal, employing a two-pronged approach that includes both single-subject studies with individually adaptive models and large-scale studies utilizing high-dimensional inference and machine learning techniques. This methodological flexibility allows him to target clinical, scientific, and operational objectives, ensuring a faster route to impactful outcomes. Nachev's research contributions fall within the realms of neurology and brain repair, aiming at advancing understanding and treatment options for neurological conditions.