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Pascal Kaeser is a professor in the Department of Neurobiology at Harvard Medical School. His research focuses on understanding the molecular mechanisms that underlie the functions and plasticity of neurotransmitter release sites. Kaeser's laboratory investigates the complexities of synaptic transmission, particularly at active zones, which are specialized sites at presynaptic nerve terminals where neurotransmitter release occurs. His work explores how these active zones consist of multi-domain proteins that orchestrate the ultrafast membrane trafficking processes required for synaptic communication. Additionally, his laboratory is exploring the role of non-classical neurotransmitters, particularly neuromodulators such as neuropeptides and dopamine, in regulating neuronal activity and their implications in neuro-psychiatric disorders. Employing molecular biochemical methods, optogenetic analyses, and gene targeting in mice, Kaeser's research aims to dissect the intricate mechanisms controlling neurotransmitter release and synaptic plasticity, thereby contributing to a more profound understanding of synaptic function and related pathologies.
Administered by the Division of Medical Sciences (DMS). GRE is not required and will not be considered for BBS, Immunology, and Neuroscience.