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Paschalis Kratsios is an Associate Professor in the Department of Neurobiology at the University of Chicago. His research focuses on the molecular mechanisms controlling motor neuron development and function, utilizing model systems such as Caenorhabditis elegans and mice. Kratsios employs advanced methodologies including whole genome sequencing and CRISPR genome editing to explore gene regulatory mechanisms. The lab aims to systematically test the function of gene regulatory factors and investigate their roles across species, particularly in understanding spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS). He has received multiple NIH grants, including the R01NS118078, to support his work on motor neuron terminal identity and the identification of transcriptional targets necessary for motor neuron subtype function. Kratsios has also been awarded the K99/R00 Pathway Independence Award from the National Institutes of Health during the years 2013-2018. His research significantly contributes to the basic science of neurobiology, focusing on novel transcription factors and cis-regulatory elements critical for motor neuron identity and function.
Department of Philosophy