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Patrick John Casey is a distinguished professor in the Department of Biochemistry at Duke University, where he focuses his research on transmembrane signaling mediated by guanine nucleotide-binding regulatory proteins (G proteins). His laboratory studies the signaling pathways that control cell growth and the effects of mutations in G proteins that lead to cell transformation. A significant area of his research involves covalent modifications of G proteins, particularly protein prenylation, which is critical for membrane targeting functions. His work has identified key enzymes involved in prenylation, such as protein farnesyltransferase and geranylgeranyltransferase-1, which have become major targets in the development of anti-cancer therapeutics. Additionally, he explores the molecular targets and effects of G12 proteins in cancer progression and their role in cellular adhesion and migration. Patrick has been a recipient of numerous grants from the National Institutes of Health and other institutions, underscoring his contributions to the field of cancer biology and pharmacology.
Duke University • Durham, NC
Leading research in biochemistry and pharmacology with a focus on G-protein signaling.
National University of Singapore-Duke Graduate Medical School •
Oversaw research initiatives and collaborations.
Duke University •
Conducted advanced research in the Department of Biochemistry.
Center for Chemical Biology •
Directed research and educational programs in chemical biology.
Duke University •
Engaged in teaching and research in molecular cancer biology.
Department of Biomedical Engineering (MS program)