Dr. Patrick Loria

Biography

J. Patrick Loria is a Professor in the Department of Chemistry at Yale University, where he has been a faculty member since 2001. His research interests focus on the molecular biophysics and biochemistry of enzyme function, exploring how conformational motion, including reorganization of catalytic groups and domain movements, plays a crucial role in catalysis and protein-ligand interactions. He employs solution nuclear magnetic resonance (NMR) spectroscopy as a primary experimental tool to gain atomic-resolution insights into enzyme kinetics, thermodynamics, and mechanisms of motion. His work significantly contributes to understanding allosterism, dynamic structural properties of proteins, and the design of de novo enzymes. Loria earned his B.S. from George Washington University in 1990 and his Ph.D. from the University of Notre Dame in 1997. After completing a NIH postdoctoral fellowship at Columbia University, he joined the Yale faculty. Loria has received several prestigious awards, including the Camille Henry Dreyfus New Faculty award and the NSF CAREER Award, and has published numerous influential articles in high-impact journals.

Research Interests

Experience