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Dr. Patrick Meraldi leads a research group focusing on the fundamental mechanisms of cell division, specifically in the context of cancer. His research investigates how the deregulation of these mechanisms contributes to genetic instability in cancer cells. The group’s objective is to understand the processes that lead to accurate chromosome segregation, emphasizing the importance of the mitotic spindle and kinetochores in this process. The lab employs high-resolution quantitative light microscopy and extensive image analysis, alongside chemical genetic perturbations, to gain insights into the activities that ensure proper cell division. They particularly explore how defects in these processes can lead to pathologies such as primary microcephaly and cancer, with findings indicating that around 85% of solid human tumors exhibit aneuploidy, which is linked to chromosomal instability. This research is critical for identifying potential targets for novel anti-cancer treatments.
University of Geneva • Genève, Switzerland
Leading research on cell division mechanisms in cancer.
Includes Department of Management, Finance, Economics, and Statistics programs. GMAT is strongly encouraged but not mandatory for most GSEM masters.