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Patrick Seale is a Professor in the Biomedical Graduate Studies at the Perelman School of Medicine, University of Pennsylvania. His research focuses on the biology of adipose (fat) cells and their substantial roles in whole-body physiology. The lab investigates the dynamic and plastic nature of adipose tissue, including its regulatory functions in metabolism, energy storage, and immune responses. The Seale lab aims to elucidate the mechanisms governing the development and remodeling of adipose tissue in response to environmental stimuli such as cold exposure and dietary factors. He is dedicated to understanding how adipocytes—both white and brown—function and adapt, as well as how alterations in adipose tissue contribute to obesity and related metabolic disorders, including type 2 diabetes. Seale's lab also explores the therapeutic potential of brown fat and mechanisms of adipocyte differentiation, with an emphasis on identifying pathways that could promote healthier metabolic profiles and mitigate the risks associated with obesity related diseases.
Perelman School of Medicine, University of Pennsylvania • Philadelphia, PA
Leading research on adipose tissue biology and its implications for metabolism and obesity.
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