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The Castel laboratory is focused on understanding the molecular mechanisms underlying oncoprotein-mediated transformation. The research employs biochemical methods, cell signaling techniques, mouse modeling, and pharmacological approaches to examine the functions and regulation of oncoproteins in cancer and congenital disorders. The lab has a particular interest in the RAS family of GTPases, known drivers of cancer and neurodevelopmental syndromes. Current projects include studying the contributions of RAS protein effectors to disease, exploring the regulation of RAS signaling components via ubiquitination and proteasomal degradation, and developing cellular and mouse models to replicate RAS-driven diseases. Overall, the research program aims to provide novel mechanistic insights into the complex processes of transformation, with the goal of identifying and developing innovative therapeutic strategies for cancer.
Open Program in Biomedical Sciences (Vilcek Institute) covers departments like Biochemistry, Pathology, Neuroscience, Microbiology, etc.