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Paul Bertone studied computer science and machine learning while carrying out his PhD in molecular computational biology at Yale University. He produced a high-resolution transcription map of the human genome, identifying genome-wide data on transcription factor binding sites in human cells through proteome-wide assays of biochemical function. He joined the European Molecular Biology Laboratory (EMBL) based research group at the European Bioinformatics Institute (EMBL-EBI), applying functional genomics to stem cell biology and embryonic development. His team determined the regulatory circuitry governing self-renewal in pluripotent cells across human and mouse models, focusing on the transcriptional, epigenetic, and chromatin remodeling factors orchestrating lineage commitment and exit from pluripotency during early differentiation. Bertone's lab later moved to the University of Cambridge, where they identified key transcriptional regulators of naïve pluripotency and characterized authentic naïve human pluripotent cells, as well as resolving a comprehensive time course of human preimplantation development using single-cell expression data. They performed cross-species analyses of embryogenesis in mouse, human, and non-human primates. Currently, Bertone's lab at Brown University focuses on cancer genomics, specifically studying tumor-initiating neural stem cells that drive the onset and progression of glioblastoma multiforme (GBM).
Department: Department of Economics