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Paul Brenchley is an Honorary Professor at the University of Manchester specializing in autoimmune diseases, particularly focusing on the mechanisms of membranous nephropathy, a rare glomerulopathy associated with heavy proteinuria and a common cause of nephrotic syndrome in adults. His research group has been active since 2009, investigating the autoimmune mechanisms that lead to this condition. Brenchley developed an ELISA to quantify circulating anti-PLA2R antibodies in patients and linked these levels to specific patient characteristics and clinical management. His research has identified significant genetic risk factors, including associated risk genes such as HLA DQA1 *05:01 and DQB1 *02:01. Additionally, he has contributed to major global studies confirming the risk genes for membranous nephropathy and identifying potential T cell epitopes related to the disease. Brenchley collaborates with various experts in the field and has a robust academic network.
University of Manchester • Manchester, UK
Leading research on autoimmune mechanisms and clinical management related to membranous nephropathy.
Includes MSc in Advanced Electrical Power Systems and MSc in Communications and Signal Processing.