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Paul J. Gadue is a Professor in the Department of Pathology Laboratory Medicine at the Perelman School of Medicine at the University of Pennsylvania. With a Ph.D. in Immunology from the University of Pennsylvania, his research program focuses on human development, particularly on endoderm and mesoderm specification using human embryonic and induced pluripotent stem cells. Dr. Gadue's work studies critical aspects of cell fate decisions during development through in vitro differentiation of embryonic and iPS cells. His laboratory investigates hematopoiesis, with a focus on megakaryocyte development and optimizing platelet generation from stem cells. Additionally, he develops in vitro models for platelet disorders using iPS cells derived from patients with genetic diseases, utilizing CRISPR/Cas9 technology to create patient-specific models. His work aims to understand the molecular mechanisms regulating endoderm and mesoderm development and explores pancreatic beta cell specification to generate functional beta cells for diabetes research.
Wharton Doctoral programs cover fields like Finance, Marketing, Management, and Operations, Information and Decisions.