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Paul J. Hagerman is a Professor at the University of California, Davis, within the Department of Biochemistry and Molecular Medicine and an investigator at the UC Davis MIND Institute. His research focuses on the molecular underpinnings of fragile X family disorders, which are neurodevelopmental and neurodegenerative in nature, such as fragile X syndrome and fragile X-associated tremor/ataxia syndrome (FXTAS). The laboratory aims to understand the mechanisms of FMR1 gene expression alterations that lead to these disorders and the development of targeted therapies. These disorders present a range of clinical features, including cognitive decline, anxiety, and various forms of tremor and ataxia. Dr. Hagerman has been involved in significant discoveries related to FXTAS, proposing that 'RNA toxicity' may play a key role in the pathogenesis of these conditions. He is actively publishing influential work on fragile X syndrome and FXTAS, addressing the genetic basis and therapeutic interventions for these disorders.
UC Davis MIND Institute • Davis, CA
Conducting research on molecular mechanisms underlying fragile X syndromes and associated neurodegenerative disorders.
Department of Computer Science. GRE is NOT required.