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Paul Janmey is a Professor in the Department of Physiology at the University of Pennsylvania's Perelman School of Medicine. His research expertise focuses on the cytoskeleton, phosphoinositide signaling, and cell mechanics. He leads a lab that investigates various aspects of cell mechanics, including the production of soft materials and hydrogels. His team's research explores how stiffness of surfaces alters cell structure, function, and growth, particularly in endothelial cells, fibroblasts, neurons, and astrocytes, which demonstrate unique dependencies on substrate stiffness. Janmey's lab employs a variety of imaging, scattering, and rheologic methods to measure the structure and mechanics of cytoskeletal polymers. Additionally, the lab examines how changes in cell membrane structure, mediated by inositol phospholipids, lead to the production of signals that remodel the cytoskeleton.
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