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Paul Janmey is a Professor in the Department of Physics and Astronomy at the University of Pennsylvania, where he also holds an adjunct position in Physiology. His research interests focus on cell mechanics, exploring how the mechanical properties of soft materials and hydrogels influence cell adhesion, structure, function, and growth. Janmey's laboratory investigates the unique dependence of endothelial cells, fibroblasts, neurons, and astrocytes on substrate stiffness, aiming to understand how cells sense and respond to mechanical cues. His team employs advanced imaging, scattering, and rheological methods to study the viscoelasticity of cytoskeletal polymer networks and to analyze changes in cell membrane structure mediated by inositol phospholipids that lead to signaling production and cytoskeletal remodeling. Janmey has contributed significantly to the field through notable publications that delve into neurite branching on deformable substrates, phosphoinositide regulation of the actin cytoskeleton, and the inhibition of platelet procoagulant activity by flavonoids. He is affiliated with various groups, including the Institute for Medicine and Engineering and the Pennsylvania Muscle Institute.
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